Christine Taylor is Ellen in The Van Buren Boys (Season 8 - Episode 14).

Cindy Ambuehl is Sophie in The Burning (Season 9 - Episode 16).

Connie Sawyer is Old Woman in The Butter Shave (Season 9 Episode 1).

Courteney Cox is Maryl Seinfeld in The Wife (Season 5 Episode 17).

Courtney Taylor is Attractive Applicant in The Secretary (Season 6 Episode 9).

Cynthia Ettinger is Michele in The Parking Garage (Season 3 Episode 6).

Cynthia Madvig is Woman #1 in The Caddy (Season 7 Episode 12).

Cynthia Szigeti is Sherry Becker in The Library (Season 3 - Episode 5).

Dale Raoul is Dental Patient in The Note (Season 3 Episode 1).

Dana Wheeler-Nicholson is Shelly in The Doodle (Season 6 Episode 19).

Darlene Kardon is Mrs. Lupchek in The Conversion (Season 5 Episode 11).

Dawn Arnemann is Monica in The Cafe (Season 3 Episode 7).

Dayna Winston is Carol in The Virgin (Season 4 Episode 10).

De Dee Pfeiffer is Victoria in The Opposite (Season 5 Episode 22).

Debi A. Monahan is Chelsea Lang in The Trip (Season 4 Episode 1).

Deborah May is Elsa in The Puffy Shirt (Season 5 - Episode 2).

Debra Jo Rupp is Katie, Jerry’s assistant in The Diplomat's Club (Season 6 Episode 22) and in The Abstinence (Season 8 Episode 9).

Debra Messing is Beth Lookner in The Wait Out (Season 7 Episode 21) and in The Yada Yada (Season 8 Episode 19).

Debra Mooney is Mrs. Sweedler in The Bris (Season 5 Episode 5).

Denise Dowse appears in 2 episodes: 1) The Wallet (Season 4 Episode 5) and 2) The Couch (Season 6 Episode 5).

Denise Poirier is Arlene in The Race (Season 6 Episode 10).

Denise Richards is Molly Dalrymple in The Shoes (Season 4 Episode 16).

Derya Ruggles is Woman in Bar in The Virgin (Season 4 Episode 10).

Diana Bellamy is Mrs. Riccardi in The Andrea Doria (Season 8 Episode 10).

Diana Castle is Mrs. Zanfino in The Wait Out (Season 7 - Episode 21) and in The Foundation (Season 8 - Episode 1).

Diana Theodore is Remy Temple in The Couch (Season 6 - Episode 5).

Donna Evans is Lola in The Handicap Spot (Season 4 Episode 22).