Sab Shimono is Executive #1 in The Checks (Season 8 Episode 7).

Sam Lloyd is Ricky in The Cigar Store Indian (Season 5 Episode 10) and in The Pie (Season 5 Episode 15).

Samantha Smith is Hallie in The Friars Club (Season 7 Episode 7).

Sandy Baron is Jack Klompus in 6 episodes. The first The Pen (Season 3 Episode 3).

Sandy Ward is Pop Lazzari in The Gum (Season 7 Episode 10) and in The Bottle Deposit (Season 7 Episodes 21-22).

Sarah Silverman is Emily, Kramer's girlfriend in The Money (Season 8 Episode 12).

Scott Burkholder is Prisoner in The Airport (Season 4 Episode 12).

Scott LaRose is Greg in The Wife (Season 5 Episode 17).

Scott N. Stevens is Intern in The Pony Remark (Season 2 - Episode 2).

Scott Patterson is Billy in The Sponge (Season 7 Episode 9).

Shannon Holt is Carrie in The Seven (Season 7 Episode 13).

Shannon K. Dunn is Elaine's Co-Worker in The Fire (Season 5 Episode 20).

Shannon Kenny is Allison in The Susie (Season 8 - Episode 15).

Shannon Whirry is Cute Girl in The Butter Shave (Season 9 Episode 1).

Sharon Barr is Trucker in The Keys (Season 3 Episode 22).

Sharon McNight is Nurse in The Heart Attack (Season 2 Episode 8).

Shashi Bhatia is Flower Girl in The Wig Master (Season 7 Episode 18).

Shaun Toub is Pinter Ranawat in The Betrayal (Season 9 Episode 8).

Shelley Malil is Usher in The Betrayal (Season 9 Episode 8).

Sheree North is Babs Kramer in The Switch (Season 6 Episode 11).

Sherman Howard is Roy Kordic in The Junior Mint (Season 4 Episode 20).

Shireen Crutchfield is Mickey, Model #2 in The Bizarro Jerry (Season 8 Episode 3).

Shuko Akune is Receptionist in The Package (Season 8 Episode 5).

Sid Newman is Old Man in The Nap (Season 8 Episode 18).

Siobhan Fallon Hogan is Tina Robbins in 3 episodes. The first: The Deal (Season 2 Episode 9).

Sonya Eddy is Rebecca de Mornay in The Muffin Tops (Season 8 Episode 21) and in The Bookstore (Season 9 Episode 17).

Spencer Klein is Kid in The Race (Season 6 Episode 10).