Louise can't have sex. In general for six weeks. Se has mononucleosis. The abstinence turns George into a genius.
According to Jerry, George's brain consists of two parts: the intellect, represented by a tiny piece of lettuce, and the part obsessed with sex (the large piece of lettuce).
With no-sex-Louise, the previously useless lump, is now functioning for the first time in its existence.
* Two Guys, a Girl and a Pizza Place